Simian Virus 40 Infection Down-Regulates the Expression of Nitric Oxide Synthase in Human Mesothelial Cells
Open Access
- 15 June 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 64 (12) , 4082-4084
- https://doi.org/10.1158/0008-5472.can-04-0486
Abstract
The cytotoxic effects of asbestos are partly mediated by the production of free radicals, including nitric oxide (NO). SV40 has been suggested to synergize with asbestos in the pathogenesis of malignant mesothelioma. Crocidolite asbestos fibers induced in human mesothelial and malignant mesothelioma cells a significant increase of NO synthase activity and expression, which was absent in SV40-infected cells. Furthermore, SV40 infection prevented the NFκB activation elicited by crocidolite in both mesothelial and mesothelioma cells. These data suggest that SV40, by inhibiting the synthesis of NO, could favor the survival of transformed, potentially neoplastic cells.Keywords
This publication has 13 references indexed in Scilit:
- Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF‐kB activationFEBS Letters, 2003
- New developments about the association of SV40 with human mesotheliomaOncogene, 2003
- SV40 replication in human mesothelial cells induces HGF/Met receptor activation: A model for viral-related carcinogenesis of human malignant mesotheliomaProceedings of the National Academy of Sciences, 2001
- Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicityProceedings of the National Academy of Sciences, 2000
- The molecular basis of asbestos induced lung injuryThorax, 1999
- Asbestos Fibers and Interleukin-1 Upregulate the Formation of Reactive Nitrogen Species in Rat Pleural Mesothelial CellsAmerican Journal of Respiratory Cell and Molecular Biology, 1998
- Signal transduction through NF-κBImmunology Today, 1998
- Asbestos, the Mesothelial Cell and Malignancy: A Matter of Life or DeathAmerican Journal of Respiratory Cell and Molecular Biology, 1997
- Novel Cell Imaging Techniques Show Induction of Apoptosis and Proliferation in Mesothelial Cells by AsbestosAmerican Journal of Respiratory Cell and Molecular Biology, 1997
- Absence of p53 mutations in malignant mesotheliomas.American Journal of Respiratory Cell and Molecular Biology, 1997