Transposons and Integrons: Natural Genetic Engineering of Bacterial Resistance
Open Access
- 1 January 1999
- journal article
- Published by Wiley in Canadian Journal of Infectious Diseases and Medical Microbiology
- Vol. 10 (C) , 5C-8C
- https://doi.org/10.1155/1999/619276
Abstract
The advent of antibiotics in clinical medicine has resulted in the emergence of multiresistant strains of bacteria. Bacteria possess sophisticated mechanisms of genetic exchange that have driven their recent evolution. Among these are transposons and integrons, the latter having interesting parallels with genetic engineering techniques used in the laboratory. An understanding of these mechanisms through studies of the molecular basis of the dissemination of resistance genes will aid rational choices in antibiotic therapy.Keywords
Funding Information
- Medical Research Council of Canada (MT-13564)
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