IN VIVO HEMOLYSIS PRODUCED BY SOAP INJECTION

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Abstract
In dogs anesthetized with barbital, the rate of red blood cell destruction was detd. by collection of bile and quantitative analysis of the bile pigment excretion. The intraven. inj. of as little as 5.0 mg. of soap or fatty acid/kg. produced a definite increase in erythrocyte destruction. Red cell destruction was greater when larger quantities of fatty acid or soap were injected. Bile pigment excretion started to increase in the course of the hr. during which the fatty acid or soap was injected. In some cases the increased secretion persisted for some hrs. after the inj. was stopped. Calculations from these and other data indicate that absorbed free fatty acids and soaps from the fat of a normal diet are responsible for the lytic destruction of a significant proportion of the daily red blood cell destruction in a normal human being. Estimated conservatively, red cell destruction from this cause is from 8-35% of the total daily destruction. Further support is lent to the concept that absorption of the products of fat digestion into the lymphatics is an adaptive mechanism, preventing excessive destruction of erythrocyte.

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