Outbreak of Hand-Feet-and-Mouth Disease among Indian and Eskimo Children in a Hospital

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Abstract
An outbreak of hand-foot-and-mouth disease (HFMD) occurred in 1968 among Indian and Eskimo children on a pediatric ward for tuberculous patients in Edmonton. Thirty-three children and 32 members of the staff were studied. One hundred percent of the children four years old or younger, 89% of those five to 12 years old, and 28% of the adults were proved to be infected with coxsackievirus A 16. The clinical syndrome of HFMD developed in 87% of the children four years old or younger, in 33% of those five to 12 years old, and in 3% of the adults. Examination of the patients' sera for neutralizing antibodies was very valuable in confirming the clinical diagnosis as well as in detecting asymptomatic infections. Neutralizing antibodies developed slowly but continued to increase in titer for as long as a year in eight of the nine patients examined in this period.

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