DIFFERENTIAL DEVELOPMENT OF ANGIOTENSIN II RECEPTOR SUBTYPES IN THE RAT BRAIN
- 1 January 1991
- journal article
- Published by The Endocrine Society in Endocrinology
- Vol. 128 (1) , 630-632
- https://doi.org/10.1210/endo-128-1-630
Abstract
Angiotensin II receptors in selected brain areas were characterized into two distinct subtypes by displacement with specific antagonists. The receptor subtypes had different developmental patterns. Type-1 receptors, selectively displaced by the specific angiotensin antagonist DuP-753, were predominant in adult (8-weeks-old) rats. Type-2 receptors were selectively displaced by CGP 42112 A and were expressed remarkably in young (2-weeks-old) rats.Keywords
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