Immobilization stress induces vasodepressor and altered neuroendocrine responses in the adult stroke‐prone spontaneously hypertensive male rat
- 8 December 1993
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 149 (4) , 491-501
- https://doi.org/10.1111/j.1748-1716.1993.tb09647.x
Abstract
The effects of acute (1 h) and daily repeated immobilization stress (14 days, twice-daily, 1 h) were studied on arterial blood pressure and heart rate and on the blood levels of several hormones in the adult (5 months old) stroke-prone spontaneously hypertensive rat (SHRSP) and in the age-matched normotensive Wistar-Kyoto (WKY) rat. The major result was the development of a long-lasting vasodepressor response in the SHRSP, while the same acute or repeated immobilization stress in the WKY rat led to the development of a prolonged vasopressor response. Differential changes to stress were also observed in practically all neuroendocrine axes with the exception of the pituitary-adrenal axis. The vasodepressor response to immobilization stress in SHRSP may be related to an exaggerated defence-like reaction causing an enhanced vasodilation in the skeletal muscle beds associated with a tachycardia similar to that in the normotensive control rats.Keywords
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