Studies of 3-Aminopyridine adenine dinucleotide phosphate
- 1 August 1975
- journal article
- review article
- Published by Springer Nature in Molecular and Cellular Biochemistry
- Vol. 8 (2) , 89-96
- https://doi.org/10.1007/bf02116237
Abstract
3-Aminopyridine adenine dinucleotide phosphate (AADP) was prepared from NADP and 3-aminopyridine through the pig brain NADase-catalyzed pyridine base exchange reaction. The purified dinucleotide was chemically characterized and spectral properties of the compound were determined. The importance of the application of AADP in studies of NADP-requiring biochemical processes was indicated by the demonstration of AADP as an effective inhibitor of five NADP-requiring enzymes, by the demonstration of the fluorescence enhancement on the binding of AADP to yeast glucose-6-phosphate dehydrogenase when glucose-6-phosphate is present, and by the functioning of AADP as a fluorimetric substrate for snake venom nucleotide pyrophosphatase.Keywords
This publication has 18 references indexed in Scilit:
- Carbon-13 nuclear relaxation measurements in nicotinamide adenine dinucleotide and adenosine monophosphateJournal of the American Chemical Society, 1974
- Nuclear magnetic resonance studies on pyridine dinucleotides. I. The pH dependence of the carbon 13 nuclear magnetic resonance of nicotinamide adenine dinucleotide.1973
- Interactions of 3-Aminopyridine Adenine Dinucleotide with DehydrogenasesJournal of Biological Chemistry, 1973
- Bull semen nicotinamide adenine dinucleotide nucleosidase. 3. Properties of the substrate binding site.1972
- Bull semen nicotinamide adenine dinucleotide nucleosidase. I. Purification and properties of the enzyme.1971
- Investigation of the conformation of β-diphosphopyridine nucleotide (β-nicotinamide adenine dinucleotide) and pyridine dinucleotide analogs by proton magnetic resonanceBiochemistry, 1968
- Glucose 6-Phosphate Dehydrogenase (Zwischenferment). II. Homogeneity Measurements and Physical Properties of the Crystalline Apoenzyme from Yeast*Biochemistry, 1967
- The Conformation of Pyridine Dinucleotides in SolutionJournal of Biological Chemistry, 1966
- The Thionicotinamide Analogs of DPN and TPN. I. Preparation and Analysis*Biochemistry, 1963
- Inhibition of Spleen Diphosphopyridine Nucleotidase by Nicotinamide, An Exchange ReactionJournal of Biological Chemistry, 1953