CHANGES IN CELLULARITY AND-OR WEIGHT OF MOUSE HEMATOPOIETIC TISSUES AS A MEASURE OF ACUTE RADIATION EFFECTS
- 1 January 1980
- journal article
- research article
- Vol. 28 (1) , 9-18
Abstract
Simultaneous determinations of the spleen weight loss, and thymus and femoral bone marrow cell depletion at approximately 45 h after whole-body irradiation were a simple, rapid, sensitive and economical way of quantitating radiation damage to the mouse hemopoietic system. Within the dose range of 45-300 rad of 250 kV X-rays the log of the radiation effect for all 3 end-points was proportional to the log dose, with the extrapolated common threshold dose of 29 .+-. 3 rad and 50% decrease relative to control values following 330 (extrapolated), 54 and 109 rad in the spleen wt, and thymus and bone marrow cellularities, respectively.This publication has 8 references indexed in Scilit:
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