Acute Toxicity of Aflatoxin B1 in the Dog
Open Access
- 1 July 1966
- journal article
- research article
- Published by SAGE Publications in Pathologia veterinaria
- Vol. 3 (4) , 331-340
- https://doi.org/10.1177/030098586600300403
Abstract
This work is a study of the acute effects of aflatoxin B1 in dogs. The dog has a remarkable susceptibility to aflatoxin B1 given by oral and intraperitoneal routes. Intraperitoneal administration resulted in the shortest survival time and the most profound pathological changes. However, massive single oral doses produced lesions of similar nature and intensity. Oral administration of aflatoxin in small, divided doses, over extended periods proved to be less toxic. The experimentally induced disease resembled hepatitis X in many respects.This publication has 5 references indexed in Scilit:
- Histopathologic lesions in ducklings caused by Aspergillus flavus cultures, culture extracts, and crystalline aflatoxinsToxicology and Applied Pharmacology, 1964
- Hepatomas in Rats and Hepatorenal Injury in Ducklings Fed Peanut Meal or Aspergillus flavus ExtractPathologia veterinaria, 1964
- Aflatoxins B and GJournal of the American Chemical Society, 1963
- A DISEASE OF SWINE AND CATTLE CAUSED BY EATING MOLDY CORN .2. EXPERIMENTAL PRODUCTION WITH PURE CULTURES OF MOLDS1957
- AN EPIZOOTIC OF HEPATITIS IN THE DOG1952