Population and formal genetics of the human C81(?-?) polymorphism

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Abstract
One hundred and ninety-six unrelated healthy individuals and 30 families with 75 offspring have been studied for the C81(α-γ) polymorphism. The following allele frequencies were calculated: C81*A=0.5536; C81*B=0.4286; C81*A1=0.0178. Observed and expected phenotype frequencies were in a good agreement according to the Hardy Weinberg law. No exceptions from the mode of inheritance were found. In family W the segregation of the rare allele C81*A1 could be followed. Comparing the results of this study with previous data from Boston and Oslo, a combined technology including C8-dependent lysis and C8 structural variation is suggested for future investigations.