Etiology of nondisjunction: lack of evidence for genetic control

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Abstract
Evidence for genetic control of meiotic nondisjunction was not found in a religious isolate of Amish in northern Indiana. Sixteen mongols were ascertained, and each had 47 chromosomes without evidence of mosaicism. Through the use of detailed family records, pedigrees were assembled for the propositi. The 16 comparison sibships were matched for maternal age and sibship size and selected at random from the same population. Mean inbreeding coefficients for the parents, grandparents, and great-grandparents were not significantly different between the two groups.

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