THE EFFECT OF ADRENALECTOMY ON THE CONTENT AND TURNOVER OF SODIUM AND POTASSIUM IN VARIOUS ORGANS

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Abstract
The Na and K content per 100 mg fresh tissues were determined by flame photometry for normal and adrenalectomised male rats. Radioisotopes Na24 and K42 were used to study Na and K exchange in the organs. A rise in K content occurred in most tissues following adrenalectomy and the Na content diminished in all organs except the liver and bone. There was a decrease in the K and an increase in the Na turnover. It was concluded that following adrenalectomy, the permeability of the cell membrane decreases for K ions and increases for Na ions. Polarization of the cell membrane was discussed.