Postnatal Development of Carrier-Mediated Absorption of Disodium Cromoglycate from the Rat Lung
- 1 July 1979
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 161 (3) , 285-288
- https://doi.org/10.3181/00379727-161-40537
Abstract
The antiasthmatic drug, disodium cromoglycate (DSCG), is absorbed from the lungs of the 6 day old rat in part by a carrier-type transport process and in part by diffusion. The carrier process is saturated at DSCG concentrations greater than 25 mM and is inhibited by certain other organic anions including phenol red, benzylpenicillin and p-aminohippuric acid. The carrier-mediated absorption process is present in the lungs of rats as young as 1 day old, but the process does not appear to become quantitatively mature until an age of 6 days when the transport rate is 2-3 times greater than that seen at the age of 1-3 days.This publication has 1 reference indexed in Scilit:
- Independence of Bile Acid and Ouabain Hepatic Uptake: Studies in the Newborn RatExperimental Biology and Medicine, 1978