Pharmacokinetics of theophylline in swine: a potential model for human drug bioavailability studies
- 1 September 1981
- journal article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 4 (3) , 233-239
- https://doi.org/10.1111/j.1365-2885.1981.tb00735.x
Abstract
The pharmacokinetics of theophylline in swine were investigated following die oral and intravascular administration of single doses of theophylline free base. The mean half‐life of theophylline following intravascular administration was 11.0 h, and the apparent specific volume of distribution was 0.61 liter/kg. Following oral administration, theophylline in solution was absorbed quite rapidly with a bioavailability of 79%. The similarity of the pharmacokinetics of theophylline in swine and humans suggests that swine may provide a useful model for the study of the bioequivalency of theophylline dosage forms intended for human use. The pharmacokinetic characteristics of theophylline also favor its consideration for usage as a therapeutic agent in swine.Keywords
This publication has 3 references indexed in Scilit:
- Influence of diet and fluid on bioavailability of theophyllineClinical Pharmacology & Therapeutics, 1975
- Statistical estimations in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1974
- Rapidly achieved plasma concentration plateaus, with observations on theophylline kineticsClinical Pharmacology & Therapeutics, 1972