Effects of the Ultimobranchial and Parathyroid Glands on Sodium and Water Excretion in the Frog11

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Abstract
Adult male Rana pipiens with either the ultimobranchial (UBX) and/or parathyroids (PTX) removed were maintained in fresh water and transferred to deionized water or a mild sodium load (fresh water with a 0.05M NaCl added). Urinary excretion rates (UER) were determined and correlated with alterations in total excretion of endogenous creatinine, sodium and calcium. In fresh water UBX frogs displayed a transitory diuresis after three days, whereas PTX and UBX-PTX exhibited oliguria after the seventh postoperative day. The UER was directly proportional to total sodium loss in all groups. Under a mild sodium load, UER increased about 75% in controls and 15% in UBX frogs, but remained unchanged in PTX and UBX-PTX frogs. The mild sodium load increased the calcium excretion rate to a proportional molar ratio of Na:Ca to 36– 39:1 in all groups. When transferred from fresh water to deionized water all groups displayed an increased UER when compared to the UER of frogs kept in fresh water; the increase in UER was associated with an increased GFR. While in deionized water the sodium loss was depressed in all frogs; however, total calcium excretion remained unchanged or slightly elevated. Calcium excretion was influenced by both parathyroids and ultimobranchial extirpation, although the calcium excretion in UBX frogs appeared to be independent of the sodium and water movement influenced by the parathyroids. (Endocrinology94: 940, 1974)

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