THE BIOASSAY OF OXYTOCIN: INCREASED SENSITIVITY OF THE RAT UTERUS IN RESPONSE TO SERIAL INJECTIONS OF STILBOESTROL

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Abstract
SUMMARY (1) Three daily injections of stilboestrol resulted in a thirteenfold increase in uterine sensitivity to oxytocin compared with that of uteri from rats in normal oestrus. These sensitive uteri have been used extensively for routine bioassay of oxytocin. The index of precision was 0·055 in six 'trial' assays. (2) The results are discussed in relation to other sensitive assay procedures for oxytocin. The present method is as sensitive and accurate but more simple and economical.

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