Iron Overload and the Predisposition of Cells to Antioxidant Consumption and Peroxidative Damage
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 7 (3-6) , 307-313
- https://doi.org/10.3109/10715768909087956
Abstract
We have investigated the effects of iron overload in vivo on the tocopherol levels and the extent of lipid peroxidation in rat liver microsomes and their response to subsequent oxidative stress in vitro. The results demonstrate a direct correlation between consumption of antioxidant defences and the induction and extent of malondialdehyde production in microsomes prepared from iron-loaded rats. The data are consistent with the requirement for iron (II)/iron (III) ratios in lipid peroxidation in control microsomes.Keywords
This publication has 21 references indexed in Scilit:
- The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin EEuropean Journal of Biochemistry, 1988
- Vitamin E protects proteins against free radical damage in lipid environmentsBiochemical and Biophysical Research Communications, 1987
- The role of iron in the initiation of lipid peroxidationChemistry and Physics of Lipids, 1987
- A method for removal of trace iron contamination from biological buffersFEBS Letters, 1987
- The role of iron in ferritin- and haemosiderin-mediated lipid peroxidation in liposomesBiochemical Journal, 1985
- Pathogenesis of hepatic fibrosis in experimental iron overloadBritish Journal of Haematology, 1985
- Characterization of iron-mediated peroxidative injury in isolated hepatic lysosomes.Journal of Clinical Investigation, 1985
- Copper complexes at N- and C-site of ovotransferrin: Quantitative determination and visible absorption spectrum of each complexBiochemical and Biophysical Research Communications, 1984
- A simplified method for cyanogen bromide activation of agarose for affinity chromatographyAnalytical Biochemistry, 1974
- Long-term Chelation Therapy in Thalassaemia Major: Effect on Liver Iron Concentration, Liver Histology, and Clinical ProgressBMJ, 1974