Examination of the Utility of the Rat as an Animal Model for Human Anticoagulation

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Abstract
The feasibility of employing the rat as an experimental model for investigation of full-dose heparin anticoagulation was assessed. Striking similarities were found to exist between rats and humans regarding (1) baseline-activated partial thromboplastin time (APTT) values, and (2) dosage per kilogram of heparin required to produce an APTT value of 1 ½-3 times normal, the clinical definition of full-dose heparinization. Based upon these similarities, it appears that the rat can effectively serve as an experimental model for investigating the effects of heparin in humans.

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