The Complete Nucleotide Sequence of the Chicken Ovotransferrin mRNA

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Abstract
The nucleotide sequence of an almost double‐stranded cDNA copy [Cochet, M., Perrin, F., Gannon, F., Krust, A., Chambon, P., McKnight, G. S., Lee, D. C., Mayo, K. E., and Palmiter, R. D. (1979) Nueleic Acids Res. 6, 2435–2452] of chicken ovotransferrin (conalbumin) mRNA has been determined. Taking into account the previously reported 5′‐end sequence [Cochet, M., Gannon, F., Hen, R., Maroteaux, L., Perrin, F., and Chambon, P. (1979) Nature (Lond.) 282, 567–574] we present the complete nucleotide sequence of the ovotransferrin mRNA from which the amino acid sequence of the protein is inferred. A computer and statistical analysis of the nucelotide sequence reveals a pattern of internal homology which confirms that the present‐day chicken ovotransferrin gene (and by extrapolation the transferrin genes of other species) has evolved by duplication and gives some support to the quadruplication hypothesis of transferrin evolution.