Immunological and enzymatic studies of erythrocytic ?-aminolevulinate dehydratase
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Internationales Archiv für Arbeitsmedizin
- Vol. 55 (1) , 87-96
- https://doi.org/10.1007/bf00378071
Abstract
The δ-aminolevulinate dehydratase (ALA.D) quantitative assay on a centrifugal fast analyser showed that subjects whose blood-lead level varies between 30 and 75 μtg/100 ml (1.5 to 3.75 μM/l) react to blood intoxication by synthesizing de novo an amount of enzyme correlating to blood-lead levels. At higher concentrations, the reactional synthesis occurs very rarely. These results suggest that enzyme is constitutive, but also inductible as soon as its substrate accumulates; this last ability may disappear at high blood-lead levels: a hypothesis is proposed thereafter.Keywords
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