mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR
- 1 October 2011
- journal article
- research article
- Published by Elsevier in Molecular Cell
- Vol. 44 (2) , 317-324
- https://doi.org/10.1016/j.molcel.2011.09.005
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTORMolecular Cell, 2011
- mTOR: from growth signal integration to cancer, diabetes and ageingNature Reviews Molecular Cell Biology, 2010
- Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and StressMolecular Cell, 2010
- mTOR signaling and drug development in cancerNature Reviews Clinical Oncology, 2010
- mTOR signaling at a glanceJournal of Cell Science, 2009
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their SurvivalCell, 2009
- βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits ApoptosisMolecular Cell, 2009
- Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability ProfilingScience, 2008
- Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancerNature Reviews Cancer, 2008
- Control of chromosome stability by the β-TrCP–REST–Mad2 axisNature, 2008