INHIBITION OF EXOCRINE PANCREATIC-SECRETION BY ALPHA-ADRENERGIC BLOCKING-AGENTS IN CONSCIOUS RATS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 243  (1) , 164-176
Abstract
The effects of the .alpha.-adrenergic blocking agents, phentolamine and phenoxybenzamine were tested on the exocrine pancreatic secretion of conscious rats. Phentolamine (0.156-1.25 mg/kg) and phenoxybenzamine (1.25 and 2.5 mg/kg) strongly inhibited basal volume and protein secretion. Phentolamine had no effect on the cholecystokinin-pancreozymin or urecholine stimulated exocrine pancreatic secretion. The infusion of phentolamine (1.25 mg/kg per h) greatly impaired the stimulatory effect on protein secretion induced by soybean trypsin inhibitor and oleic acid. .alpha.-Adrenergic blocking agents inhibit pancreatic secretion of the conscious rat by impairment of cholecystokinin-pancreozymin release by a direct inhibitory action or by blocking a still unknown .alpha.-adrenergic stimulatory reflex present in the duodenal mucosa.

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