Immuno-electrophoretic Analysis of Proteins in Serum and Synovial Fluid in Rheumatoid Arthritis and Ankylosing Spondylitis

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Abstract
Immuno- electrophoretic analysis was performed on sera from 43 patients with rheumatoid arthritis and 22 patients with ankylosing spondy-litis, on synovial fluid from eight patients with rheumatoid arthritis and on urine from two patients with rheumatoid arthritis complicated by renal disease. In many sera from patients with rheumatoid arthritis and ankylosing spondylitis there were increased amounts of alpha-1 and alpha -2 glycoproteins. The most constant finding in both groups was an increased amount of beta- 2 macroglobulin. In sera from some patients, a double arc of gamma globulin was found. The significance of this finding is discussed. Immuno-electrophoretic patterns of synovial fluid and urine were com-pared with the patterns of sera from the same patients.