THIOURACIL. ITS ABSORPTION, DISTRIBUTION, AND EXCRETION 1

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Abstract
Using a colorimetric method for the estimation of thiouracil the author studied a number of the biochemical properties of thiouracil in rats and man, as well as in vitro. The drug was rapidly absorbed from the gastro-intestinal tract and readily excreted in the urine. Most of the thiouracil in the blood was found in the cells, the red cells containing a larger total amt. than the white cells. The drug was distributed throughout essentially all the tissues and fluids of the body, the larger quantities being in the bone marrow, thyroid, ovaries, pituitary and milk. Many tissues of the body caused destruction of thiouracil. Some of the drug was also destroyed by the gastro-intestinal contents. In human subjects, when the total daily dosage of thiouracil is from 0.4 g. to 0.1 g., approx. 1/3 of this is excreted in the urine as thiouracil but none is excreted in the stools.

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