Is there an osmotic threshold for vasopressin release?

Publisher Website
Google Scholar
Abstract
This question typifies a recurring problem in experimental physiology, viz., the discrimination between competing models. The editorial controversy that is outlined indicates the need for further exploration of the questions at hand, based on the statistical principles of experimental design and analysis. The problem emphasizes the need for thorough evaluation of the validity and precision of radioiimmunoassay data and indicates the necessity for scrupulous quality control. Ideally, all relevant measurements should be made in the same assay. Hypothesis testing may then be based directly on the raw counts, rather than on the derived potency estimates. Use of more sophisticated statistical tests should help to extract maximal information from the available data.

This publication has 0 references indexed in Scilit: