Synthesis of 2-(Substituted Methyl)-3,4-Disubstituted Pyrroles and Their Conversion into the Corresponding Porphyrins
- 1 October 1992
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 65 (10) , 2660-2667
- https://doi.org/10.1246/bcsj.65.2660
Abstract
2-Hydroxymethyl-1-methylsulfonyl-3,4-disubstituted pyrroles and 2-hydroxymethyl-3,4-disubstituted pyrroles were effectively converted into the corresponding 2-(substituted methyl)pyrrole derivatives by the reaction with various nucleophiles in the presence of base. These products were further transformed to the corresponding porphyrins regioselectively under almost neutral or basic conditionsKeywords
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