Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes
Open Access
- 25 February 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 181 (2) , 308-312
- https://doi.org/10.1016/0014-5793(85)80282-9
Abstract
Insulin and EGF cause identical stimulation(≅40%) of fatty acid synthesis in hepatocytes isolated from rats which have been starved and then refed a low‐fat diet. In both cases this stimulation is associated with increased phosphorylation of ATP‐citrate lyase and of a specific site on acetyl‐CoA carboxylase. However, the altered phosphorylation of acetyl‐CoA carboxylase is not associated with a change in kinetic parameters which is detectable in the purified enzyme. Whatever the mechanism involved, stimulation of fatty acid synthesis by growth factors may have a role in providing new phospholipid for growth of membranes.Keywords
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