The effects of changes in haematocrit on renal function

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Abstract
Acute changes in total body hematocrit were produced in anesthetized dogs by the rapid infusion of packed red cells, dextran solution or hypertonic mannitol. A reduction of hematocrit resulted in a decrease in filtration fraction.and a rise of hematocrit in an increase in filtration fraction. A direct relationship between water reabsorp-tion (relative to filtered load) packed cell volume (P.C.V.) was also observed. The changes in filtration fraction accompanying changes in hematocrit may be mediated largely by a passive alteration of efferent arteriolar resistance resulting from modifications of blood viscosity.