Granulocyte function in untreated pernicious anaemia

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Abstract
Neutrophil granulocyte functions were evaluated in 9 patients with pernicious anemia (PA). Membrane potential, O2 consumption, nitroblue tetrazolium reduction and phagocytosis and killing of staphylococci were determined prior to the institution of vitamin B12 therapy. There were no significant alterations in these granulocyte functions as compared with normal controls, although in several patients low values were seen. In PA the oxidative metabolism and microbicidal functions of granulocytes in general are normal, even in severely anemic patients.