Distribution of high energy phosphate in normal and dystrophic muscle

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Abstract
On a noncollagen protein basis, the creatine phosphate and the total creatine of the dystrophic muscles was lower than in normal muscle. The ratio of creatine phosphate to creatine was the same as for normal muscle; the high energy nucleotide phosphate was better maintained than the creatine phosphate. Assuming a normal synthesis of creatine, the low content of creatine and creatine phosphate in dystrophic muscle is consistent with a high creatine excretion. The failure to retain creatine is not due to the lack of adenosine triphosphate for its synthesis.