[4,4′‐D‐Diaminopropionic acid]gramicidin S: a synthetic gramicidin S analog with antimicrobial activity against Gram‐negative bacteria
- 5 September 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 161 (1) , 89-92
- https://doi.org/10.1016/0014-5793(83)80736-4
Abstract
Gramicidin S is especially active against Gram-positive bacteria; e.g., Staphylococcus aureus. An analog, [4,4′-D-diaminopropionic acid]gramicidin S, which contains D-diaminopropionic acid residues instead of D-phenylalanine residues, has been synthesized. This analog is active against some of the Gram-negative bacteria; e.g., Escherichia coli and Salmonella typhosa. Activities of several related analogs are discussed.Keywords
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