Very large and isotypically atypical polyclonal plaque‐forming cell responses in mice infected with Trypanosoma cruzi
- 1 January 1985
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 15 (2) , 201-203
- https://doi.org/10.1002/eji.1830150219
Abstract
Normal C3HIHeJ mice, acutely infected with T. cruzi, develop large numbers of splenic Ig-secreting plaque-forming cells (PFC). IgG2a, IgG2b and IgGl PFC account for over 90% of all PFC, while the numbers of IgG3- and IgA-secreting PFC are lower than in normal animals. These effects appear to be due to both T helper-dependent regulation and to a mitogenic activity associated with the parasites themselves.Keywords
This publication has 12 references indexed in Scilit:
- Release of lipopolysaccharide (LPS) from cell surface of Trypanosoma cruzi by EDTAInternational Journal for Parasitology, 1983
- Isotype commitment in the in vivo immune responses. II. Polyclonal plaque‐forming cell responses to lipopolysaccharide in the spleen and bone marrowEuropean Journal of Immunology, 1983
- Distinct helper activities control growth or maturation of B lymphocytesEuropean Journal of Immunology, 1983
- A “Trans” Perspective on the Control of Immunoglobulin C Gene ExpressionImmunological Reviews, 1982
- Trypanosoma cruzi: Effect on B-cell-responsive and -responding clonesExperimental Parasitology, 1981
- Immunity to Trypanosoma cruziAdvances in Parasitology, 1980
- Autoimmume and polyclonal B cell responses during murine malariaNature, 1978
- Lipopolysaccharide-Induced Suppression of the Primary Immune Response to a Thymus-Dependent AntigenThe Journal of Immunology, 1977
- A plaque assay for all cells secreting Ig of a given type or classEuropean Journal of Immunology, 1976