Studies on psychotropic agents. II. Synthesis of 1-substituted-3-(p-fluorophenacyl)piperidines and the related compounds.
- 1 January 1977
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 25 (8) , 1911-1922
- https://doi.org/10.1248/cpb.25.1911
Abstract
A series of 1-substituted-3-phenacylpiperidine derivatives and 1-substituted-3-(p-fluorophenacyl)pyrrolidine derivatives were synthesized for pharmacological testing. Conversion of 3-phenacyl-4-piperidone derivatives into 4,5,6,7-tetrahydrofuro(or -1H-pyrrolo)[3,2-c)pyridine derivatives, rearrangement of quaternary salts of these products with phenylithium and dimerization of the dehydration product of 1-benzyl-3-hydroxymethyl-4-piperidone were described. Among the compounds synthesized, 1-(p-fluorobenzoyl)propyl-3-(p-fluorophenacyl)-pyrrolidine showed remarkable CNS depressing activities.This publication has 2 references indexed in Scilit:
- Studies on psychotropic agents. I. Synthesis of 3,8-disubstituted-1-oxa-3,8-diazaspiro(4,5)decan-2,4-dione derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- Ueber die Derivate des Acetophenonacetessigesters und des AcetonylacetessigestersEuropean Journal of Inorganic Chemistry, 1884