Fetal Maturity Assessed from Biochemical Analysis of the Liquor AMNII

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Abstract
Two hundred and fifty-one samples of liquor amnii were analysed to determine the correlation between the biochemical constituents of the liquor and gestational maturity. Creatinine, oestriol and protein were the only constituents which, measured individually, correlated with maturity. The difference between the levels of creatinine in the amniotic fluid and maternal serum and the ratio of amniotic fluid to serum creatinine gave a lower percentage exact prediction than creatinine alone. Computing together all five parameters gave a prediction of gestational maturity to within 2 weeks in 73 per cent of cases. The biochemical content of the liquor amnii probably principally reflects maturation of fetal renal function, which does not necessarily correlate accurately with gestational maturity.

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