Effects of selective ultraviolet phototherapy (SUP) and local PUVA treatment on DNA synthesis in guinea pig skin

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Abstract
The treatment with UV-light with wavelengths between 292.5–335 nm (known as selective UV-phototherapy, or SUP) and 320–390 nm (plus local treatment with8-methoxypsoralen, known as PUVAex) gave rise to a biphasic reaction of epidermal cell proliferation in guinea pig skin. A decrease of proliferative activity was followed by a synchronized stimulation of DNA synthesizing cells after 2–4 h. These quantitative displacements were accompanied by qualitative changes in the proliferative behaviour of epidermal cells in the S-compartment. Exposition von UV-Licht mit den Wellenlängen 292,5–335 nm (selektive UV-Phototherapie; SUP) und 320–390 nm (plus lokaler Behandlung mit 8-Methoxypsoralen; PUVAex) führte in der Meerschweinchen-Haut zu einer biphasischen Reaktion der epidermalen Zellproliferation. Im Anschluß an eine verminderte Proliferationsaktivität setzte eine synchronisierte Stimulationswelle von DNS synthetisierenden Zellen nach 2–4 h ein. Neben diesen quantitativen Verschiebungen traten qualitative Veränderungen im Proliferationsverhalten epidermaler Zellen innerhalb des S-Kompartments auf.