Effect of prolactin on urinary excretion and renal haemodynamics in conscious rats.

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Abstract
Conscious rats received a saline infusion (5.8 ml/h) via a tail vein, for a 6 h period. For the final 2 h of this infusion period, prolactin (7.1 .mu.g/100 g body wt per h) was incorporated in the infusate. A control group of animals continued to receive saline alone. In the 1st hour of prolactin administration (in comparison with the control group), urine flow, Na output and osmolal output were all significantly reduced (P < 0.02); there was also a reduction (P < 0.05) in renal plasma flow (p-aminohippurate clearance), but the filtration fraction did not alter. The changes in urinary excretion, and in renal hemodynamics, did not persist for the 2nd hour of prolactin administration, but there was a sustained increase in body fluid volume. Altered renal hemodynamics apparently are responsible for the reduced urinary water and solute excretion which occurs during acute prolactin administration.