Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12–q21
- 1 August 1996
- journal article
- letter
- Published by Springer Nature in Nature Genetics
- Vol. 13 (4) , 461-463
- https://doi.org/10.1038/ng0896-461
Abstract
Wilms' tumour (WT) Is one of the most common solid tumours of childhood, occurring in 1 in 10,000 children and accounting for 8% of childhood cancers. It is believed to result from malignant transformation of abnormally persistent renal stem cells (nephrogenic rests) which retain embryonic differentiation potential1. Although WT is usually sporadic, approximately one percent occur in families in which susceptibility appears to be inherited as an autosomal dominant trait with incomplete penetrance1. Predisposition to other cancers or to the developmental abnormalities associated with sporadic WT is not usually apparent in WT families. The WT1 gene at 11p13 (ref. 2), and additional genes on chromosomes 11p15 (ref. 3) and 16q (ref. 4) have been implicated in the development of WT but are not responsible for familial WT5–8. We have carried out a genome linkage search in a large Canadian family with seven confirmed cases of WT. Our results provide strong evidence for the localisation of a familial WT predisposition gene, FWT1, to an 18-centi-morgan (cM) interval on chromosome 17q12–q21.Keywords
This publication has 19 references indexed in Scilit:
- The 1993–94 Généthon human genetic linkage mapNature Genetics, 1994
- The Human Insulin-like Growth Factor-Binding Protein 4 Gene Maps to Chromosome Region 17q12-q21.1 and Is Close to the Gene for Hereditary Breast-Ovarian CancerGenomics, 1993
- Wilms' tumor in the Li-Fraumeni cancer family syndromeCancer Genetics and Cytogenetics, 1993
- Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumourNature, 1993
- Evidence that WT1 mutations in Denys — Drash syndrome patients may act in a dominant-negative fashionHuman Molecular Genetics, 1993
- Familial predisposition to wilms tumor does not segregate with the WT1 geneGenomics, 1991
- Lack of linkage of familial Wilms' tumour to chromosomal band 11 p13Nature, 1988
- Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11Nature, 1988
- Wilms tumor in three patients with Bloom syndromeThe Journal of Pediatrics, 1987
- The Perlman syndrome: Familial renal dysplasia with Wilms tumor, fetal gigantism and multiple congenital anomaliesAmerican Journal of Medical Genetics, 1984