HEMMUNG DER UTERUSWIRKUNG VON OXYTOCIN DURCH WASSERLÖSLICHE STEROIDE

Publisher Website
Google Scholar
Abstract
Various water-soluble steroids were tested in vitro on the isolated rat uterus for their oxytocin-antagonistic activities. Using progestional agents (19-nor-17α-hydroxyprogesterone-17-hemisulfate-sodium, Δ1,6-17α-hydroxyprogesterone-17-hemisulfate-sodium) oestrogens (oestrone-hemisulfate-sodium), and corticoids (dexamethasone-21-hemisulfate-sodium) it was possible to suppress both the oxytocin-induced single contraction and the spontaneous rhythm intensified by oxytocin. Except for the Δ1,6-17α-hydroxyprogesterone-sulfate-sodium, these compounds were unable to inhibit the single contractions of the uterus induced by serotonin, bradykinin and barium chloride. Following the administration of a mixture of the different watersoluble steroids an additional effect was observed. Based on these results, it can be assumed that the oxytocinantagonistic effect represents an activity per se which is peculiar to certain steroid structures.

This publication has 5 references indexed in Scilit: