Use of Genetic Linkage for the Detection of Female Carriers of Hemophilia

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Abstract
IT is usually not possible to ascertain if a female is a carrier of hemophilia unless she has a hemophilic son or is the daughter of a hemophilic father. Although assay of factor VIII in female carriers shows lower concentrations than in normal persons, sufficient overlap occurs to reduce the value of the assay for detecting the carrier state. Furthermore, the question may become most acute after pregnancy is established, when many clotting factors including factor VIII are increased over pre-pregnancy values. Accordingly, a female relative of a patient with this disease may have considerable anxiety about the likelihood that . . .