Ureaplasma Urealyticum and Infertility: The Effect of Different Antibiotic Regimens on the Semen Quality

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Abstract
Objective criteria of of semen quality were evaluated in 243 men treated for Ureaplasma urealyticum genital tract infection with 1 of 4 different antibiotic regimens. Significant improvement was observed in motility, quantity, quality and percentages of oval and small forms. Doxycycline, whether used for 2 or 4 wk, at a dosage of 100 mg twice daily resulted in the same cure rate (79 and 81%, respectively). Tetracycline regimens of 500 mg 3 times daily for 2 or 4 wk had significantly inferior cure rates (17 and 55%, respectively). Evidently, antibiotic therapy could be valuable in improving semen quality when Ureaplasma is isolated, and followup culture for the organism should decide the endpoint in therapy, since resistant strains for doxycycline and tetracycline are emerging.