EFFECT OF CYCLIC ADENOSINE-MONOPHOSPHATE ON RENAL-FUNCTION AND RENIN SECRETION

  • 1 January 1975
    • journal article
    • research article
    • Vol. 46  (1) , 9-18
Abstract
The effect of c[cyclic]AMP, infused into the renal artery, on renal function and on the release of renin was studied in dogs displaying a normal serum Na level. Intrarenal infusion of 1 mg/kg per min of cAMP caused a significant increase in RBF [renal blood flow], dilatation of the efferent arterioles, the redistribution of RBF and a significant increase in tubular Na-reabsorption. The antidiuretic action of cAMP was due partly to a hemodynamic and partly to a direct tubular effect. Decreased renin secretion was explained by the Na-load on the macula densa segment, being decreased by the intrarenal shifting of RBF and with an eventual decomposition of cAMP.