QUANTITATIVE HISTOLOGICAL ANALYSIS OF ANTIGEN-INDUCED ARTHRITIS IN THE RABBIT
- 1 October 1988
- journal article
- research article
- Vol. 69 (5) , 739-748
Abstract
Antigen-induced arthritis in the rabbit (AIAR) provides the closest experimental equivalent to human rheumatoid arthritis in terms of infiltration of synovial tissue by lymphoid cells. A method is described for quantitative histological analysis of AIAR. Measurements of total cell numbers, lymphocyte and polymorphonuclear leucocyte infiltration, and thickness of infiltrated synovium were obtained for ranges of antigen dosage and duration of arthritis. The method has been devised as part of a system for the analysis of joint swelling, synovial fluid biochemistry and cytology, cartilage proteoglycan chemistry and synovial histology on the same specimen.This publication has 5 references indexed in Scilit:
- Synthesis of arachidonate oxidation products by synovial joint tissues during the development of chronic erosive arthritisArthritis & Rheumatism, 1987
- Local cell populations in experimental arthritidesInflammation Research, 1986
- Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.Proceedings of the National Academy of Sciences, 1986
- Preparation of Whole Rabbit Knee Joints for Microscopic ExaminationStain Technology, 1986
- PRODUCTION OF ARTHRITIS IN RABBITS BY AN IMMUNOLOGICAL REACTION TO FIBRIN1962