Dose-Dependent Effect of Atrial Natriuretic Peptide on Blood Pressure, Heart Rate, and Skin Blood Flow of Normal Volunteers
- 1 January 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 8 (1) , 216-220
- https://doi.org/10.1097/00005344-198601000-00031
Abstract
Synthetic atrial natriuretic peptide, containing 26 amino acids in rat sequence, L-364,343 (Ileu-ANP), was infused intravenously at increasing rates (1-40 .mu.g/min) into four normal volunteers. Mean intraarterial blood pressure decreased and heart rate increased in cumulative-dose-dependent fashion. Skin blood flow as measured with a laser Doppler device rose already with a cumulative dose of 55 .mu.g Ileu-ANP and further rises were directly related to dose. The only side effects observed were those accompanying symptomatic hypotension at higher doses. These findings provide strong evidence that Ileu-ANP acts as a vasodilator in normal volunteers.This publication has 2 references indexed in Scilit:
- Ca-dependent hemodynamic and natriuretic effects of atrial extract in isolated rat kidneyAmerican Journal of Physiology-Renal Physiology, 1984
- Comparative vasoactive effects of native and synthetic atrial natriuretic factor (ANF)Biochemical and Biophysical Research Communications, 1984