A 356-Kb Sequence of the Subtelomeric Part of the MHC Class I Region
- 1 January 1999
- journal article
- research article
- Published by Taylor & Francis in DNA Sequence
- Vol. 10 (4-5) , 263-299
- https://doi.org/10.3109/10425179909033955
Abstract
The subtelomeric part of the MHC Class I region contains 11 of the 21 genes described on chromosome 6 at position 6p21.3. The general organization of those and other genes resident in the region was revealed by determining a 356,376 bp sequence. Potential exons for new genes were identified by computer analysis and a large number of ESTs were selected by testing the sequence by the BLAST algorithm against the Gen-Bank nonredundant and EST databases. Most of the ESTs are clustered in two regions. In contrast, the whole HLA-gene region is crammed with LINE and SINE repeats, fragments of genes and microsatellites, which tends to hinder the identification of new genes.Keywords
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