Distinct Effect of G-CSF on the Growth and Differentiation of Myeloid Progenitor Cells from Chronic Idiopathic Neutropenia.
- 1 January 1995
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 34 (5) , 384-387
- https://doi.org/10.2169/internalmedicine.34.384
Abstract
Chronic idiopathic neutropenia (CIN) is a disorder characterized by severe neutropenia and a maturational arrest of the neutrophil precursors in the bone marrow. We examined the effect of recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the growth and maturation of the myeloid progenitor cells from a patient with CIN. The patient's marrow cells showed poor colony forming activity, but a normal differentiating capacity to the stimulation with rhG-CSF, although they displayed a normal colony forming capacity in the presence of GM-CSF. Our observation indicates the distinct effect of rhG-CSF on the growth and maturation of the myeloid progenitors from a CIN patient.Keywords
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