Cardiovascular Effects of Pinacidil and Propranolol Alone and in Combination in Normal Humans

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Abstract
The effects of long-acting formulation of pinacidil (P1134), a new arteriolar vasodilator, have been investigated in normal humans. We observed the effects of pinacidil 37.5 mg when given alone, and when given in combination wth propranlol 40 mg. The reflex tachycardia observed in the supine and standing positions after pinacidil was reduced by concurrent administration of propranolol. Combined treatment reduced systolic arterial pressure in the standing position from 117.0 .+-. 2.5 to 98.3 .+-. 3.5 mm Hg at 4 h after drug administration (p < 0.01), which was greater than the hypotensive effect produced by either drug alone. These results indicate that the combination of pinacidil and a .beta.-adrenoceptor antagonist may be of value in the treatment of arterial hypertension.