The hunt for the CIA: factors which demonstrate corticotrophin-inhibitory activity

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Abstract
In the halcyon days when life was simple, many thought that pituitary hormones were under the control of single hypothalamic factors which regulated their synthesis and release. Matters became a little more complex when the search for growth hormone (GH)-releasing hormone was punctuated by the discoveries of somatostatin, which inhibited both GH and thyrotrophin (TSH), by the co-release of TSH and prolactin by thyrotrophin-releasing hormone, and then by the substantiation of other prolactin-releasing factors such as vasoactuve intestinal peptide. It has since become increasingly clear that pituitary peptides are regulated by a whole series of hypothalamic factors, both stimulatory and inhibitory, and are also subject to intrapituitary paracrine modulation

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