THE RELATION OF THE HYPOPHYSIS AND ADRENAL CORTEX TO THE REMOVAL OF EXCESS GLUCOSE FROM THE BLOOD OF RATS

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Abstract
Intraven. sugar tolerances were detd. after 12-24 fasting periods on normal hypophyseetomized, adrenalectomized. and adrenalectomized-hypophysectomized rats which had previously been maintained on a stock diet. The 3 groups which had been operated upon showed reduced glucose tolerances. The tolerance of adrenalectomized rats was restored to normal by injs. of adrenal cortex extract, and the tolerance was largely restored by administration of Rubin-Krick salt soln. Neither procedure, however, improved the tolerance of the hypophyseetomized animals. The adrenalectomized-hypophysectomized rats showed additive effects from the double removal, both in reduced glucose tolerance and shorter life on fasting. The effect of hypophysectomy on glucose tolerance evidently was not entirely due to adrenal atrophy. Since the reduction in glucose removal in hypophyseetomized rats was during the period immediately after injection of glucose while the sugar disappeared more rapidly than normal later, it was thought that the interference was with glycogenesis. Changes in blood conc, circulation, diffusion rate, and urinary loss were shown not to be the factors involved.

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