RESPONSE OF PLASMA ALDOSTERONE TO ANGIOTENSIN II, ACTH AND POTASSIUM IN MAN

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Abstract
Plasma aldosterone, corticosterone, cortisol and renin activity have been measured in recumbent normal subjects (n = 3–4) following stimulation with angiotensin II, ACTH and potassium. Control studies on a regular sodium intake show that in the same subject aldosterone and renin activity exhibit no time dependent pattern from 7 a.m. to 11 a.m., while corticosterone and cortisol decrease continuously. Angiotensin II (infusion of 7 ng/kg/min over 1–3 h), ACTH (rapid iv injection of 0.5 mg β1-24 ACTH) and potassium (potassium citrate 30 mEq. po every hour for 3 h) on a regular Na intake induce a reproducible increase of aldosterone. The onset of this increase is observed within 10 min for angiotensin II and ACTH and within 60–90 min for potassium. The range of the rise in aldosterone is about 20–25 ng/100 ml for all 3 stimuli, corresponding to a 3–5 fold increase from basal values. Angiotensin II and potassium are, in the dose used, specific stimuli of aldosterone; ACTH however stimulates aldosterone, corticosterone and cortisol, but to a variable degree and with a different time-course response. On a low sodium intake, a similar aldosterone response pattern is found after stimulation with ACTH, but only exceptionally after stimulation with potassium; after both stimuli values of 55–75 ng/100 ml have been reached.

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