ABSORPTION AND EXCRETION OF CHORIONIC GONADOTROPIN ADMINISTERED INTRAMUSCULARLY IN WOMEN*

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Abstract
IT HAS been shown that daily doses of 10,000 international units (I.U.) of chorionic gonadotropin prolong the life of the corpus luteum in women (1). In that study, it was also observed that urinary excretion of the gonadotropin was sufficiently high to give a positive Aschheim-Zondek reaction. The factors concerned in the absorption and excretion of the injected hormone were sufficiently obscure to justify an attempt to determine whether delaying absorption might prolong the effectiveness of treatment. MATERIALS AND METHODS Women on the gynecologic ward who were waiting for elective surgical procedures were selected as test subjects. Chorionic gonadotropin (Antuitrin-S) was given as a single intramuscular injection (10,000 I.U.—either in aqueous solution, mixed with an emulsifying agent (Emulgen) or in oil and 1 per cent wax (A.P.L.). Urine was collected as successive 12-hour specimens for periods of 48 to 120 hours. The chorionic hormone concentration in this urine was determined by injection into immature female rats. The end point of the assay was the presence or absence of corpora lutea in the ovaries of the rats 96 hours after the first injection.

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